Launched in the UK at the beginning of 2005, EVOLENCE™ is a new, collagen-based dermal filler manufactured by ColBar LifeScience (now part of OrthoNeutrogena, a division of Ortho-McNeil Pharmaceutical, Inc., a Johnson & Johnson company). It was officially launched in Europe in October 2004 at the 13th EADV Congress in Florence, Italy.
It is intended for the correction of wrinkles, nasolabial folds, scars, atrophy from disease or trauma, defects secondary to rhinoplasty (nose surgery), skin graft or other surgically-induced irregularities and other soft tissue defects or deficiencies.
EVOLENCE™ is supplied in a single-use syringe and is composed of 1 ml (35 mg/ml) of highly purified, cross-linked porcine collagen dispersed in phosphate buffered saline solution.
What does it contain?
The highly purified collagen in EVOLENCE™ is derived from porcine (pig) tendons.
Due to their high degree of compatibility with the human body’s immune system, porcine collagen materials are often used in human medicine, e.g., in heart valve replacements, implantable lenses, and surgical wound dressings.
How is it made?
Using their patented Glymatrix™ technology, they firstly break down the source material into pure collagen molecules. Then they re-create the strong, long-lasting bonds that exist in nature using a naturally occurring sugar, ribose. The result is a collagen substantial enough to fill even deep facial contours instantly but with a low viscosity making it easy to inject.
Is a skin test required before treatment?
EVOLENCE™ is natural product and due to the Glymatrix™ technology it is able to mimic the properties of the natural collagen found in the skin. Therefore, while an allergic reaction is theoretically possible, it is extremely rare so pre-testing is not required before treatment with EVOLENCE™.
However, patients with a history of hypersensitivity, particularly known allergies to collagen, should consult their doctor about having a skin test performed first.
Is it temporary or permanent?
EVOLENCE™ is a long lasting temporary filler, which the manufacturers claim will last at least 12 months.
Collagen is completely broken down within the skin over a period of months, eventually leaving no trace of the filler.
Should be used by
Trained members of the medical profession only.